Status:
COMPLETED
Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Lead Sponsor:
King's College London
Collaborating Sponsors:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Sarcopenia
Frailty
Eligibility:
All Genders
60-120 years
Phase:
NA
Brief Summary
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older...
Detailed Description
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of skeletal muscle mass and strength occurs with incre...
Eligibility Criteria
Inclusion
- Aged \>=60 years
- Dietary protein intake of \<1.3g/kg/day
- Able to consent
- Able to access video calls on a device such as laptop/tablet
Exclusion
- Severe food allergy
- Current or recent antibiotic use (preceding 3 months)
- Currently or recent use of protein or leucine supplements (preceding 3 months)
- Currently or recent use of probiotic or prebiotic food supplements (preceding 3 months)
- Current or prior history of gastrointestinal disease e.g. gastrointestinal cancer, inflammatory bowel disease, bariatric surgery, irritable bowel syndrome
- history of any significant injury or surgery which currently affects physical functioning and ability to undertake chair stand test
- weight loss of ≥5% of body weight in preceding 6-12 months
- Currently involved in other intervention studies
- Any condition or circumstance likely to interfere with the normal conduct of the study and interpretation of the results, as judged by the investigators As the study population are over 60 years old, it is assumed that there will be no pregnant women who are eligible to take part.
Key Trial Info
Start Date :
April 29 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 20 2021
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT04309292
Start Date
April 29 2021
End Date
December 20 2021
Last Update
October 27 2022
Active Locations (1)
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1
Department of Twin Research and Genetics
London, United Kingdom