Status:
UNKNOWN
Knee Osteoarthritis Treatment With Percutaneous Injections of Autologous Bone Marrow Concentrate
Lead Sponsor:
Istituto Clinico Humanitas
Conditions:
Knee Osteoarthritis
Cartilage Degeneration
Eligibility:
All Genders
40-70 years
Brief Summary
Recently there has been a growing interest in the role of subchondral bone in knee arthritis, both in its etiology and evolution and in its clinical significance. It has now been widely demonstrated t...
Detailed Description
Osteoarthritis (OA) is a chronic degenerative and disabling disease of joint joints, in which metabolic impairment between the synthesis and degradation of cartilage and subchondral bone, involves pro...
Eligibility Criteria
Inclusion
- Male or female patients aged between 40 and 70;
- Medial or lateral arthrosis (grade 2-3 according to Kellgren-Lawrence score);
- Failure after at least 6 months of conservative treatment (patients not responding to drug therapy with NSAIDs and painkillers, no benefit from rehabilitation cycle in water or gym, no benefit after hyaluronic acid or platelet-rich plasma (PRP) infiltrations, or after at least one infiltration of corticosteroids);
- Ability and consent of patients to participate actively in the rehabilitation and clinical and radiological follow-up protocol;
- Signing of informed consent.
Exclusion
- Patients who are incapable of understanding and will;
- Trauma patients within 6 months prior to surgery;
- Patients with malignancies;
- Patients with rheumatic diseases;
- Patients with diabetes;
- Patients with metabolic thyroid disorders;
- Patients abusing alcoholic beverages, drugs or drugs;
- Patients with lower limb impairment above 10°
- Body Mass Index \<18 or \> 35;
- Patients undergoing knee surgery during the 12 months prior to surgery;
- Patients with pathology ascribable to patellofemoral pathology;
- Untreated knee instability.
Key Trial Info
Start Date :
June 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2022
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT04310852
Start Date
June 6 2018
End Date
January 31 2022
Last Update
March 17 2020
Active Locations (1)
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1
Humanitas Research Hospital
Rozzano, Milan, Italy, 20089