Status:
COMPLETED
Endogenous Glucose Production in Patients With Glycogen Storage Disease Type Ia
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
Ultragenyx Pharmaceutical Inc
Conditions:
Glycogen Storage Disease Type IA
Eligibility:
All Genders
16+ years
Phase:
PHASE1
PHASE2
Brief Summary
Glycogen storage disease type Ia (GSDIa) subjects retain a limited capacity for endogenous glucose production (EGP). To date, the origin of residual EGP in GSDIa patients is unknown. Either increased ...
Detailed Description
Study design: An investigator-initiated human pilot-study. Study population: Ten adult subjects with GSDIa and ten age and gender-matched healthy subjects. Interventions: Three experiments will be pe...
Eligibility Criteria
Inclusion
- The diagnosis should be confirmed by G6PC mutation analysis
- Age above 16 years
- Stable medical condition before the start of the test procedures
Exclusion
- Age \< 16 years
- Intercurrent illness
- Recent history of hospitalization due to hypoglycemia
- Pregnancy
- History suggestive of diabetes or fasting intolerance
- First grade family member with a confirmed diagnosis associated with fasting intolerance
Key Trial Info
Start Date :
January 19 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 7 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04311307
Start Date
January 19 2021
End Date
February 7 2022
Last Update
February 11 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Groningen, UMC Groningen
Groningen, Netherlands