Status:
RECRUITING
The Beneficial Effects of Naps on Motor Learning
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Stroke
Eligibility:
All Genders
18-80 years
Brief Summary
Background: Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows th...
Detailed Description
Study Description: We will investigate the within-individual contribution of wakeful and sleep neural replay to motor skill consolidation in three groups: (a) young healthy subjects, (b) older health...
Eligibility Criteria
Inclusion
- HEALTHY VOLUNTEERS:
- INCLUSION CRITERIA:
- Age 18-35 (Arm 1) or 50-80 (Arms 2).
- English speaking.
- Clear right-hand dominance (\>74 on Edinburgh Handedness Inventory).
- Normal neurological examination as determined by the screening clinician.
- EXCLUSION CRITERIA:
- HCPS affiliated NIH staff (i.e. - staff from our section).
- Current pregnancy.
- Contraindications for MRI or MEG.
- Use of sleep medications within 24 hours of Experimental Session participation.
- Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.
- STROKE PATIENTS:
- INCLUSION CRITERIA:
- Age 18 or older
- Willing and able to provide consent
- Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis
- Ability to perform the study task as assessed during physical examination
- English-speaking
- EXCLUSION CRITERIA:
- HCPS-affiliated NIH staff (i.e. - staff from our section).
- Current pregnancy
- History of large stroke lesions in brainstem or cerebellum as determined by screening clinician
- Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis) as determined by the screening clinician
- Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders as determined by the screening clinician
- Contraindications for MRI or MEG.
Exclusion
Key Trial Info
Start Date :
March 4 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2026
Estimated Enrollment :
199 Patients enrolled
Trial Details
Trial ID
NCT04312126
Start Date
March 4 2021
End Date
August 1 2026
Last Update
August 20 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892