Status:
UNKNOWN
The Correlation Between Immunological Reaction of the Seminal Fluid in the Mother's Blood and Pregnancy Complications
Lead Sponsor:
Sheba Medical Center
Conditions:
Preeclampsia
Pregnancy Complications
Eligibility:
FEMALE
18-46 years
Brief Summary
It is known that if there isn't an efficient exposure to the paternal antigens before conception, there is an increased risk for the pre-eclampsia (PE) cascade and other pregnancy complications to tak...
Detailed Description
The pathophysiology of preeclampsia (PE) likely involves both maternal and fetal/placental factors. It has been established that poor placentation followed by oxidative stress/inflammation and abnorma...
Eligibility Criteria
Inclusion
- Age 18-45
- 50 women for each group.
- Primigravid or first insemination from a new partner/sperm donor (group I)
- Women exposed to sperm (from the same donor/partner ≥ 2 times) (Group II)
- Singleton gestation
- Obtained verbal/written consent to participate in study
Exclusion
- o Multiple gestation
- Multifetal gestation
- Chronic hypertension
- Chronic renal disease
- Autoimmune disease (antiphospholipid syndrome, systemic lupus erythematosus)
- Vascular disease
- Pregestational diabetes mellitus
Key Trial Info
Start Date :
November 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04314518
Start Date
November 1 2020
End Date
December 1 2024
Last Update
May 5 2022
Active Locations (2)
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1
Sheba medical center
Ramat Gan, Israel
2
Tel Hashomer Hospital
Ramat Gan, Israel