Status:
COMPLETED
Verify if Amelogenins Had Some Benefits in Improving Lower 2nd Molar Periodontal Healing After 3rd Molar Extraction
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Attachment Loss, Periodontal
Teeth, Impacted
Eligibility:
All Genders
18-27 years
Phase:
PHASE4
Brief Summary
Background: Prevention of periodontal defects after the extraction of lower third molars remains a challenge. Various methods have been proposed in the literature, but there are no studies which evalu...
Eligibility Criteria
Inclusion
- Patients aged \< 27, for which the extraction of both lower third molars was indicated
- Bilateral total (bone or osteo-mucosal) third molar impaction
- Bilateral bone defect ≥ 5mm distal to the lower second molars, evaluated on pre- operative periapical radiographs performed with Rinn's film holders
- PPD ≥ 8mm distal to the second lower molars, in at least one of the following probing sites: buccal, disto-buccal, disto-central, disto-lingual
- Intra-operative integrity of both third molar buccal and lingual alveolar cortices
Exclusion
- Smoking habit
- Systemic disorders with serious immunologic impairment
- Taking cortisone or other drugs that might interfere with healing process
- Allergy to penicillins
- Previous periodontal treatment
- Less than 2 mm of adherent gingiva at second molar level
- Second molars with a prosthetic crown
- Previous endodontic treatment of second molars
- Furcation involvement of the second molars
Key Trial Info
Start Date :
March 24 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 20 2018
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT04314726
Start Date
March 24 2016
End Date
April 20 2018
Last Update
March 19 2020
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