Status:
COMPLETED
a Single HYAJOINT Plus Combined With a Single PPR Versus a Single PRP for Knee OA
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Knee OA
Eligibility:
All Genders
20-75 years
Phase:
PHASE2
Brief Summary
Intraarticular hyaluronan or platelet-rich plasma (PRP) is each effective in the treatment for knee osteoarthritis (OA). The efficacy of combined hyaluronan with PRP for knee OA remained unclear. This...
Detailed Description
Intraarticular HA or PRP has been used for knee OA for years. Combined HA and PRP has not been widely used for OA because of lack of clinical evidence. Based on in vitro and animal studies, combining ...
Eligibility Criteria
Inclusion
- Aged 20-75 years;Symptomatic knee OA \> 6 months despite conservative treatment such as oral analgesics, NSAIDs and/or physical therapy;Kellgren-Lawrence grades 2 knee OA on radiographs taken within the previous 6 months;Average pain at walking \> 30 mm on a 100-mm visual analog scale (VAS);Radiological evidence of bilateral knee OA was accepted if global pain VAS in the contralateral knee\< 30 mm.
Exclusion
- Previous orthopedic surgery on the spine or lower limbs Disabling OA of either hip or foot Knee instability, apparent joint effusion or marked valgus/varus deformity Known allergy to hyaluronan products Women ascertained or suspected pregnancy or lactating Intraarticular injections into the knee in the past 6 months Any specific medical conditions (rheumatoid arthritis, active infections, severe cardiovascular diseases, autoimmune diseases, hemiparesis, neoplasm, etc.) that would interfere with the assessments
Key Trial Info
Start Date :
August 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 10 2019
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT04315103
Start Date
August 1 2018
End Date
July 10 2019
Last Update
March 19 2020
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Physical Medicine and Rehabilitation, Veterans General Hospital,
Kaohsiung City, Taiwan, 813
2
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan, 813