Status:
COMPLETED
Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination Therapy vs. Oseltamivir Alone for Hospitalised Paediatric Influenza Patients
Lead Sponsor:
Mackay Memorial Hospital
Conditions:
Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination Therapy vs. Oseltamivir Alone for Hospitalised Paediatric Influenza Patients
Eligibility:
All Genders
1-18 years
Brief Summary
Efficacy of clarithromycin-naproxen-oseltamivir combination therapy vs. oseltamivir alone for hospitalised paediatric influenza patients
Detailed Description
This study aimed to compare the safety and efficacy of clarithromycin-naproxen-oseltamivir combination therapy to that of oseltamivir treatment alone for hospitalised paediatric influenza patients. Th...
Eligibility Criteria
Inclusion
- \- age 1 year to 18 years; body temperature higher than 38 °C; presence of one of the following symptoms-cough, sputum production, sore throat, rhinorrhoea, myalgia, headache, or fatigue presenting within 72 hours from symptom onset; laboratory-confirmed influenza infection (including rapid test or PCR-confirmed influenza A or B); and clinical requirement for hospitalisation. Antiviral treatment was initiated within 48 hours after admission.
Exclusion
- \- a history of allergy or contraindication to the study medications; the administration of medications with macrolides (ex: azithromycin, erythromycin), naproxen or neuraminidase inhibitor use within 72 hours; current use of any antibiotic; and the presence of an immunocompromised state due to steroid use, human immunodeficiency virus infection, chronic kidney disease, renal failure, chemotherapy or radiotherapy in half year, or innate immunodeficiency.
Key Trial Info
Start Date :
December 18 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 29 2019
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT04315194
Start Date
December 18 2017
End Date
December 29 2019
Last Update
March 19 2020
Active Locations (1)
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1
Mackay Children's Hospital
Taipei, Taiwan, 10449