Status:
COMPLETED
Improving Everyday Task Performance Through Repeated Practice in Virtual Reality.
Lead Sponsor:
Temple University
Conditions:
Alzheimer Disease
Mild Dementia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
There are very few effective interventions that promote functional independence in people with Alzheimer's disease (AD) and related dementias. This R21 project is the first step in the long-term goal ...
Detailed Description
Functional disability, the loss of independence in everyday tasks like meal preparation, is a core diagnostic criterion for clinical dementia/Alzheimer's disease (AD) and contributes to the disease's ...
Eligibility Criteria
Inclusion
- Inclusion/Exclusion Criteria:
- 65 years or older;
- fluency in the English language;
- availability of an informant reporter who has knowledge of the participant's daily functioning;
- no lifetime history of severe psychiatric disorder (e.g., schizophrenia, bipolar disorder), nervous system infections or disorders (e.g., epilepsy, brain tumor, large-vessel stroke, major head trauma) other than Alzheimer's disease;
- no current metabolic or systemic disorders (e.g., B12 deficiency, renal failure, cancer);
- no current major depression or moderate-severe depression symptoms;
- no current moderate - severe, uncontrolled anxiety symptoms;
- no severe sensory deficits that would preclude visual detection or identification of common everyday objects used in the study or the inability to hear the task directions (e.g., blindness, total hearing loss);
- no severe motor weakness that would preclude the use of everyday objects or the VR Training computer touch screen (e.g., severe deformities or paralysis of both upper extremities) ;
- intact estimated general intellectual functioning (i.e., no history of intellectual disability);
- available to participate in the one-month follow-up session after the VR Training (i.e., no surgery, travel, etc. scheduled over the next month);
- diagnosis of mild to moderate Alzheimer's disease within the past year, including confirmation of mild to moderate dementia on Mini Mental Status Exam (score approximately 25 or lower), significant functional difficulties reported by informant report, and cognitive impairment on demographically adjusted (age, education, sex, and race) cognitive test scores at baseline.
- An informant (N = 40) also will be recruited for each participant with dementia. Informants are people who know the participant well and interact with the participant on a daily basis. Informants will be asked to report on the participants' daily functioning and the extent to which the informant is burdened by the participants. Informants also will be asked to report on changes in medical or mental status during the study period. Informant eligibility criteria is listed below:
- 18 years of age or older
- fluency in the English language
- available and willing to complete study questionnaires in person or by phone
- has daily contact with the participant
- reports that he/she is knowledgeable of the participant's daily functioning
Exclusion
Key Trial Info
Start Date :
January 12 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04315337
Start Date
January 12 2021
End Date
March 31 2024
Last Update
July 16 2024
Active Locations (1)
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1
Temple University
Philadelphia, Pennsylvania, United States, 19121