Status:
UNKNOWN
Effect of PEEP on Subdural Pressure, Optic Nerve Sheath Diameter, Lung Compliance and Brain Perfusion Pressure
Lead Sponsor:
Istanbul University
Conditions:
Supratentorial Neoplasms
Anesthesia, General
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
We aim to determine the level of intraoperative PEEP that optimizes lung compliance without causing a rise in subdural pressure and if we can utilize optic nerve sheath diameter measurement as an indi...
Detailed Description
Application of positive end-expiratory pressure (PEEP) during general anesthesia minimizes ventilation/perfusion mismatch, intraoperative atelectasis and postoperative pulmonary complications. PEEP ap...
Eligibility Criteria
Inclusion
- Supratentorial tumor
- Elective surgery
- American Society of Anesthesiologist Class I, II or III
Exclusion
- Midline shift more than 5 mm determined by intracranial imaging
- Initial subdural pressure higher than 20 mmHg
- Requiring intravenous mannitol or hypertonic saline treatment before dural opening
- Congestive heart failure
- Pulmonary hypertension
- Sepsis
- Hypovolemia
- Obstructive or restrictive lung disease
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2021
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04316208
Start Date
March 1 2020
End Date
September 1 2021
Last Update
March 20 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Istanbul University - Cerrahpasa, Department of Neurosurgery, Neurosurgical Theaters
Istanbul, Turkey (Türkiye), 34098