Status:
UNKNOWN
Association of Copy Number Variations in the SMN Genes With Acute Kidney Injury After Heart Surgery
Lead Sponsor:
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
1-80 years
Brief Summary
This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. This study also aims to analysis the effect of SMN1+/- genot...
Detailed Description
This prospective cohort study aims to explore the susceptibility to acute kidney injury after heart surgery in SMN1+/- genotype population. Real-time PCR is used to detect copy number variations in th...
Eligibility Criteria
Inclusion
- Age: Children (1 month -17 years old) and adults (18-80 years old);
- Sex: All;
- Those who will receive selective cardiac surgery with cardiopulmonary bypass;
- Those who signed the informed consent.
Exclusion
- Those with glomerular filtration rate: eGFR\<15ml/min/1.73m2, and those who have received the renal replacement therapy before surgery;
- Those who have received nephrectomy and kidney transplantation;
- Those who have suffered from AKI before;
- Those with incomplete medical history or clinical data.
Key Trial Info
Start Date :
April 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
1206 Patients enrolled
Trial Details
Trial ID
NCT04317196
Start Date
April 1 2020
End Date
September 1 2022
Last Update
May 12 2020
Active Locations (1)
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1
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China