Status:
COMPLETED
Identification of Microbial DNA in Maternal Plasma After PPROM
Lead Sponsor:
University of California, San Francisco
Conditions:
Preterm Rupture of Membranes
Eligibility:
FEMALE
18-55 years
Brief Summary
This study evaluates the use of metagenomic next generation sequencing in identifying microbial DNA in plasma samples of patients with preterm premature rupture of membranes.
Detailed Description
Although preterm premature rupture of membranes (PPROM) occurs in only 3% of pregnancies, it accounts for 30% of preterm births (PTB) and is associated with serious maternal and neonatal morbidity. An...
Eligibility Criteria
Inclusion
- For PPROM group, preterm premature rupture of membranes between 16 0/7 and 33 6/7 weeks of gestation
- For control group, healthy pregnancy with no evidence of preterm premature rupture of membranes or other major complications
Exclusion
- Maternal age \< 18 years
- Major fetal congenital malformation
Key Trial Info
Start Date :
February 12 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT04318470
Start Date
February 12 2020
End Date
December 31 2022
Last Update
April 7 2023
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94158