Status:
COMPLETED
Allogeneic Amniotic Mesenchymal Stem Cell Therapy for Lupus Nephritis
Lead Sponsor:
Yan'an Affiliated Hospital of Kunming Medical University
Collaborating Sponsors:
The First People's Hospital of Yunnan
Conditions:
Lupus Nephritis
Mesenchymal Stem Cells
Eligibility:
All Genders
14-60 years
Phase:
PHASE1
Brief Summary
This study would further evaluate the safety and efficacy of human amniotic mesenchymal stem cell (hA-MSC) for the treatment of lupus nephritis (LN).
Detailed Description
Eleven patients with WHO class III, IV or V LN were given hA-MSC (Peripheral intravenous infusion, dose 1×106/kg cells, once every month for three times). At the same time, five patients with LN who w...
Eligibility Criteria
Inclusion
- Enrollment criteria:
- Adult patients (age 14-60 years) who were diagnosed as lupus nephritis, regardless of gender, uncontrolled disease course;
- Pathological examination of puncture biopsy resulting in diagnosis of type II, III, or IV lupus nephritis;
- SLEDAI score \>8;
- proteinuria greater than 1 g/day and active urinary sediments;
- Lupus nephritis treatment according to guidelines and norms before human amniotic mesenchymal stem cells therapy;
- If there is a possibility of pregnancy in female, must be negative pregnancy test, not in lactation, and confirm that is receiving the method of contraception recognized by the researchers, and agree to maintain the method of contraception throughout the study. Sexually active male patients must agree to the use of an appropriate contraceptive method for birth control from the first administration of the study treatment until 24 weeks after the last administration.
- The subjects should be fully informed, voluntarily sign the informed consent, and agree to participate in all visits, examinations, and treatments as required by the experimental protocol.
- Exclusion criteria:
- Patients with kidney biopsy diagnosis of type I, VI lupus nephritis or a diagnosis of another glomerular disease;
- Patients with abnormal renal function (serum creatinine ≥ the upper limit of normal);
- Patients with active liver disease or abnormal liver function test results (ALT or AST ≥2 times the upper limit of normal);
- Patients with blood leukocyte count \<2.5 × 109/L, hemoglobin \<90 g/L, platelet count \<100 × 109/L, or those who have other hematologic diseases (severe anemia, idiopathic thrombocytopenic purpura, splenomegaly, coagulation dysfunction, etc.);
- Patients with serious and unstable cardiovascular or cerebrovascular diseases (unstable angina pectoris, coronary artery disease, cerebrovascular disease, transient ischemic attack, congestive heart failure, etc.), acute and difficult to control the disease, after treatment has not been effectively controlled severe hypertension (blood pressure \>160/100 mm Hg), or organ transplantation;
- Patients with uncontrolled infection;
- Patients with tumors or abnormal tumor marker levels; 8. Patients with blood-borne diseases (i.e., HIV, syphilis, hepatitis B, and hepatitis C);
- Pregnancy, the potential for pregnancy, or lactation;
- Patients with a history of allergy, especially patients allergic to human blood albumin;
- Patients with mental illness affecting their voluntarism, ability to make decisions, and ability to communicate；
- A history of alcoholism or known drug addiction in the last 2 years;
- Participation in another clinical trial within the last 3 months;
- Patients judged inappropriate for this study by the physicians.
Exclusion
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2019
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04318600
Start Date
January 1 2014
End Date
January 1 2019
Last Update
March 24 2020
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