Status:
COMPLETED
Effectiveness of Hyaluronic Acid in the Regeneration of Infrabony Defects
Lead Sponsor:
University of Roma La Sapienza
Conditions:
Intrabony Periodontal Defect
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this randomized controlled clinical trial (RCT) is to determine the efficacy hyaluronic acid (HA) versus enamel matrix derivatives (EMD) in the treatment of infrabony periodontal defect...
Detailed Description
Intrabony defects associated with periodontal pockets represent a risk factor for periodontitis progression and additional loss of attachment if left untreated. Over the years, several strategies hav...
Eligibility Criteria
Inclusion
- Patient related:
- adults aged 18-65 years with periodontal disease
- sites with infrabony defects and persisting pockets \[probing pocket depth (PPD) ≥ 5 mm and bleeding on probing (BOP)\] at re-evaluation 6 weeks after non-surgical periodontal therapy
- full-mouth plaque score (FMPS)1 and full-mouth bleeding score (FMBS)2 \< 20% before surgery
- at least one radiographically detectable infrabony lesion,3
- good physical health.
- Site-specific:
- Interproximal angular defects on single-rooted teeth
- radiographic infrabony component ≥ 3 mm
- PPD ≥ 6 mm and CAL ≥ 7 mm.
Exclusion
- relevant medical conditions contraindicating surgical interventions
- pregnancy or lactation
- tobacco smoking
- untreated periodontal conditions
- any condition associated with poor compliance or failure to maintain good oral hygiene
- acute infectious lesions in areas intended for surgery
- teeth with grade 2 or higher mobility
- restorations or carious lesions on root surfaces that are associated with the intrabony defect.
Key Trial Info
Start Date :
September 6 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 21 2019
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT04319770
Start Date
September 6 2016
End Date
October 21 2019
Last Update
June 4 2020
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