Status:
RECRUITING
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
Lead Sponsor:
East Carolina University
Collaborating Sponsors:
Duke University
University of Arkansas
Conditions:
Metabolic Inflexibility
Eligibility:
All Genders
18-50 years
Brief Summary
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some o...
Detailed Description
Our overall hypothesis is that increased reliance on anaerobic glycolysis in muscle shifts fasting metabolism from fat towards carbohydrate utilization, which results in metabolic inflexibility and su...
Eligibility Criteria
Inclusion
- 18-50 years old
- BMI of 25 - 30 kg/m2
- BMI \> 40kg/m2
- Lactate levels in top and lower 25%
Exclusion
- Pregnant women
- Mentally disabled
- Prisoners
- Smokers
- Subjects with heart disease
- Type 1 and 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Peripheral occlusion
- Hepatic disease
- Have had weight fluctuations exceeding + 3% in the previous 12 months
- On medications which alter carbohydrate metabolism will not be studied
Key Trial Info
Start Date :
March 3 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04320264
Start Date
March 3 2020
End Date
December 1 2025
Last Update
August 7 2025
Active Locations (1)
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1
East Carolina University
Greenville, North Carolina, United States, 27834