Status:
TERMINATED
Dexamethasone Compared to Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pericarditis
Lead Sponsor:
Rabin Medical Center
Conditions:
Pericarditis Acute
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The treatment of acute pericarditis is empiric and is based on treatment with medications with anti-inflammatory properties such as non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids. H...
Detailed Description
Dexamethasone compared to Non-steroidal anti-inflammatory drugs in the treatment of acute pericarditis: a non-inferiority randomized controlled trial (Dexa-P) Objectives: The investigators hypothesi...
Eligibility Criteria
Inclusion
- Patient with first presentation of acute pericarditis (both idiopathic and post pericardiectomy)
- Patients diagnosed according to accepted clinical findings: 2 of the 4 following criteria: chest pain, pericardial friction rub, ECG changes typical for pericarditis and/or pericardial effusion.
- Patients over the age of 18 years
Exclusion
- Patient with Uncontrolled Diabetes (as defined as hyperglycaemia \>300mg/dl at presentation or HBA1C\>9% (if known))
- Patients with a known allergy to steroid therapy
- Patient with a known allergy to NSAID therapy
- Patients with a known contraindication to colchicine therapy
- Pregnancy or lactating women
- Patients with systemic fungal infection
- Patients with a known pericardial effusion of tuberculous, purulent, or neoplastic causes
- Patients with chronic steroid use
- Patients with a known rheumatological disease
Key Trial Info
Start Date :
February 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 17 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04323280
Start Date
February 14 2020
End Date
July 17 2023
Last Update
December 19 2023
Active Locations (1)
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1
Rabin Medical Center
Petah Tikva, Israel, 1234