Status:
UNKNOWN
Detection of High Expression Levels of EMT-Transcription Factor mRNAs in Patients With Pancreatic Cancer and Their Diagnostic Potential
Lead Sponsor:
Istituto Clinico Humanitas
Collaborating Sponsors:
IRCCS San Raffaele
Conditions:
Pancreatic Cancer
Eligibility:
All Genders
18+ years
Brief Summary
The present study is aimed at detecting and measuring mRNA levels of genes involved in epithelial to mesenchymal transition (EMT) in biological samples, i.e. in peripheral blood samples of pancreatic ...
Detailed Description
The investigators first provided evidence that human pancreatic cancer (PC) cells can undergo EMT during local invasion, and that EMT transcription factors (i.e.Twist family basic helix-loop-helix tra...
Eligibility Criteria
Inclusion
- Males or females over 18 years of age capable of providing informed consent.
- Pancreatic carcinoma confirmed by tissue biopsy or colon mass, clinically consistent with cancer and eventually confirmed by pathology.
- Subject were enrolled following colon cancer screening via colonoscopy
Exclusion
- Patients under the age of 18 years or over the age of 80 years.
- Patients with personal history of cancer, identification of large polyp or adenomatous pathology on previous or subsequent colonoscopy
- Patient with history of abdominal surgery within the past four months
- Patients unwilling to or unable to give informed consent.
- Patients with acute inflammatory diseases or under any emergency condition.
- Pregnant women.
Key Trial Info
Start Date :
November 2 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
850 Patients enrolled
Trial Details
Trial ID
NCT04323917
Start Date
November 2 2017
End Date
November 1 2022
Last Update
August 10 2020
Active Locations (1)
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1
Istituto Clinico humanitas
Milan, Italy, 20089