Status:
COMPLETED
Osteoarthritis Running & Cartilage Assessment
Lead Sponsor:
University of British Columbia
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Knee osteoarthritis (OA) is a debilitating disease affecting millions of Canadians. Exercise is a core treatment for knee OA, and is advocated by all clinical guidelines. However, the safety of recrea...
Eligibility Criteria
Inclusion
- ALL:
- aged greater than 40 years
- recreational runners who run at least twice per week for a total of at least 10 km, and have done so for a minimum of 12 months
- comfortable running on a treadmill for 30 minutes.
- TFOA Group:
- exhibit radiographic evidence of mild or moderate tibiofemoral osteoarthritis (TFOA) according to the Kellgren and Lawrence OA classification scale (grade ≥ 2)
- report knee pain on most days of the previous 3 months (during running and activities of daily living).
- Control Group:
- free of any radiographic signs of TFOA according to the Kellgren and Lawrence scale (grade = 0)
- pain free in both knees for the 12 months prior to recruitment.
Exclusion
- ALL:
- any history of traumatic knee injury (fracture, severe sprain, meniscus injury)
- presence of an inflammatory arthritic condition
- presence of any health condition (other than OA in the TFOA group) affecting normal movement or precludes engaging in moderate to high impact activities such as running
- use of any oral or injected corticosteroids or viscosupplementation in the previous 6 months
- any history of surgery in either knee
- standard contra-indications to magnetic resonance imaging (MRI).
Key Trial Info
Start Date :
December 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 4 2024
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT04325334
Start Date
December 1 2019
End Date
October 4 2024
Last Update
March 25 2025
Active Locations (1)
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1
Motion Analysis and Biofeedback Laboratory, The University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z3