Status:
COMPLETED
Neurobiological Drivers of Mobility Resilience: The Dopaminergic System
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Parkinsonian Signs in Older Persons
Eligibility:
All Genders
60+ years
Phase:
PHASE1
PHASE2
Brief Summary
Walking with age becomes both slower and less 'automated', requiring more attention and brain resources. As a result, older adults have a greater risk of negative outcomes and falls. There is an urgen...
Detailed Description
Walking with age becomes both slower and less 'automated', requiring more attention and prefrontal resources. As a result older adults have a greater risk of adverse mobility outcomes and falls. Walki...
Eligibility Criteria
Inclusion
- Age 60 or older (M/F)
- Evidence of mild parkinsonian signs (incl. slow gait (\< 1m/s))
Exclusion
- Presence of clinically significant degenerative joint disease and/or neuropathy interfering with proper assessment of the motor UPDRS exam.
- Presence of significant dementia.
- Evidence of a large vessel stroke in a clinically relevant area (cerebral cortex, basal ganglia, thalamus) or mass lesion on structural brain imaging (MRI).
- Participants in whom magnetic resonance imaging (MRI) is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant.
- Severe claustrophobia precluding neuroimaging procedures.
- Hypersensitivity to the carbidopa, levodopa, and tablet components.
- Any other medical history determined by investigators to preclude safe participation.
Key Trial Info
Start Date :
February 8 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2022
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04325503
Start Date
February 8 2021
End Date
June 30 2022
Last Update
April 4 2024
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Functional Neuroimaging, Cognitive, and Mobility Lab, University of Michigan
Ann Arbor, Michigan, United States, 48105