Status:
WITHDRAWN
TDCS-Augmented Prolonged Exposure Therapy
Lead Sponsor:
Medical University of South Carolina
Conditions:
Posttraumatic Stress Disorder
PTSD
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, ...
Detailed Description
This project implements a multiple baseline within-subject clinical trial design aiming to test whether tDCS targeting excitation of the medial prefrontal cortex (mPFC) can enhance a standard course o...
Eligibility Criteria
Inclusion
- Age 18-65.
- Fluent in English.
- Diagnosis of chronic PTSD based on MINI for DSM-5 (\> 3 mo. post-trauma)
- For Veterans recruited at the Ralph H. Johnson VA only: eligible to receive PE in the PCT clinic.
Exclusion
- Currently receiving psychotherapy for another anxiety- or stress-related condition.
- Unstable dose of psychotropic medications within 6 weeks prior to baseline assessment
- Medical condition that would contraindicate participation in treatment or assessment activities (e.g., severe cardiovascular problems).
- Pregnancy
- Current severe major depressive disorder
- Current, or history of bipolar disorder
- Current, or history of psychotic symptoms
- Serious suicidal risk
- Active neurological conditions, e.g., seizures, stroke, loss of consciousness or concussion
- Contraindications for tDCS:
- Metal in the head.
- Implanted brain medical devices.
Key Trial Info
Start Date :
October 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04327362
Start Date
October 1 2021
End Date
May 1 2022
Last Update
October 24 2024
Active Locations (1)
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1
National Crime Victim's Research & Treatment Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina
Charleston, South Carolina, United States, 29425