Status:
UNKNOWN
RTSS Vaccine and PBO Net Impact on Malaria Infection and Transmission in Malawi
Lead Sponsor:
Michigan State University
Collaborating Sponsors:
Kamuzu University of Health Sciences
University of Maryland, College Park
Conditions:
Malaria, Malaria Vaccine, Insecticide-treated Bednets
Eligibility:
All Genders
7-10 years
Brief Summary
The overall goal of this study is to assess the impact of RTS,S (malaria) vaccination and PBO nets on malaria infection and transmission, independently and how they interact when they are introduced t...
Detailed Description
Introduction: The decline in malaria incidence has stalled globally and incidence is increasing in some high transmission settings of sub-Saharan Africa, including Malawi. The situation is worsening d...
Eligibility Criteria
Inclusion
- Children aged 7 to 18 months of age (age-eligible for at least 3 doses of RTS,S doses) OR being one of not more than two children living in the household of an enrolled age-eligible child and being \>18 mos and \< 10 years of age.
- Not on cotrimoxazole prophylaxis for HIV infection
- Weight \>5 kg
- Permanent residence of Health Centre (HC) catchment area
- Residence within 10 km from the HC
- Written informed consent from parent/guardian for the child to participate in the study
Exclusion
- Non-residents of the catchment area and visitors to the study area will be excluded because the study requires follow-up for at least 6 months and access to interventions such as conventional, PBO nets and malaria vaccination.
Key Trial Info
Start Date :
February 4 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2024
Estimated Enrollment :
3000 Patients enrolled
Trial Details
Trial ID
NCT04327440
Start Date
February 4 2020
End Date
March 1 2024
Last Update
March 31 2020
Active Locations (1)
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1
University of Malawi College of Medicine
Blantyre, Malawi, 3