Status:
COMPLETED
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Barrett Esophagus
Proton Pump Inhibitor
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
Detailed Description
Consecutive patients with symptomatic Barrett's esophagus are recruited and receive biopsy for esophageal metaplastic mucosa and gastric mucosa over the antrum and body during endoscopy on enrollment....
Eligibility Criteria
Inclusion
- patients between the ages of 20 and 80 years
- having symptoms of acid regurgitation, heart burn, or feeling of acidity in the stomach
- having Barrett's Esophagus proven by histology confirmation
- length of esophageal metaplastic mucosa equal to or longer than 1 centimeter
Exclusion
- pregnancy,
- coexistence of serious concomitant illness (for example, decompensated liver cirrhosis and uremia)
- previous gastric surgery,
- allergic to esomeprazole,
- presence of dysplastic esophageal mucosa
- equivocal endoscopic diagnosis of Barrett's esophagus
Key Trial Info
Start Date :
February 2 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 8 2019
Estimated Enrollment :
218 Patients enrolled
Trial Details
Trial ID
NCT04329000
Start Date
February 2 2010
End Date
December 8 2019
Last Update
April 3 2020
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