Status:
TERMINATED
Sympathetic Mechanisms in the Cardiovascular and Metabolic Alterations of Obesity
Lead Sponsor:
Italo Biaggioni
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Obesity-Associated Insulin Resistance
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to study the role of sympathetic mechanisms involved in chronic regulation of cardiovascular and metabolic abnormalities seen in obesity. The investigators will study the ...
Detailed Description
Continuing Review (CR, 2021/08/04) Update: Removal of the angiotensin receptor blockade arm of the study The presence of obesity increases the risk for hypertension and diabetes, in part due to the d...
Eligibility Criteria
Inclusion
- Males and females of all races between 18 and 60 years of age
- Hypertension defined by two or more properly measured seated blood pressure readings \>130/85 mmHg or currently on antihypertensive medication.
- Obesity will be defined as having a body mass index (BMI) ≥ 30 kg/m2.
- Able and willing to provide informed consent.
Exclusion
- Pregnancy or breast feeding
- Current smokers or history of heavy smoking (\>2 packs/day)
- History of alcohol or drug abuse
- Previous allergic reaction to study medications
- Evidence of type I diabetes
- Cardiovascular disease other than hypertension
- History of serious cerebrovascular disease
- History or presence of immunological or hematological disorders
- Impaired renal function
- Treatment with any investigational drug in the 1 month preceding the study
- Inability to give, or withdraw, informed consent
- Other factors which in the investigator's opinion would prevent the subject from completing the protocol
Key Trial Info
Start Date :
February 23 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 27 2022
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04329806
Start Date
February 23 2021
End Date
July 27 2022
Last Update
September 5 2025
Active Locations (1)
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1
Vanderbilt University
Nashville, Tennessee, United States, 37232