Status:
UNKNOWN
Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial
Lead Sponsor:
Post Graduate Institute of Medical Education and Research, Chandigarh
Conditions:
Periodontal Diseases
Cirrhosis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Periodontitis is common in patients with cirrhosis and may lead to systemic sepsis. 1 Grønkjær et al demonstrated that severe periodontitis predicted higher mortality in patients with cirrhosis. 2 In ...
Detailed Description
The aim of this study is to prospectively determine the association of generalised Stage I \& II (initial to moderate) with all-cause and cirrhosis-related mortality in patients with cirrhosis. We...
Eligibility Criteria
Inclusion
- Cirrhosis of any etiology
- Aged between 18 Years to 65 Years
- Either gender
- Generalized Stage I \& II Periodontitis as defined by the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions)
Exclusion
- Inability to obtain informed consent from patient or relatives.
- Severe cardiopulmonary disease
- Pregnancy
- HIV infection
- Recent abdominal surgery (with in last 6 months)
- Patient on immunosuppressive drugs
- Malignancies including Hepatocellular carcinoma
- Gastrointestinal (GI bleed) in the last 4 weeks
- Oral antibiotics or antifungals taken in last 2 weeks.
- Active sepsis
- Stage III \& IV Periodontitis
- Localized /Molar-incisor pattern
- Patients who received periodontal treatment within the last 6 months
- Patients who require antibiotic prophylaxis before examination or treatment
- Presence of a carious exposed teeth/periapical abscess etc requiring Root Canal Treatment/extraction
Key Trial Info
Start Date :
March 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT04330469
Start Date
March 1 2020
End Date
December 30 2022
Last Update
September 28 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Postgraduate Institute of Medical Education and Research
Chandigarh, India, 160012