Status:
COMPLETED
Dissecting the Role of Estradiol in Mediating Gender-specific Anxiolytic and Prosocial Effects of Oxytocin
Lead Sponsor:
University Hospital, Bonn
Conditions:
Oxytocin
Estrogen
Eligibility:
All Genders
18-40 years
Phase:
PHASE1
Brief Summary
The study aims to examine a behavioral and neural framework for understanding the sex-specific effects of the neuropeptide oxytocin (OXT). Using hormonal, behavioral and neuroimaging readouts, it is p...
Detailed Description
The study comprises two subprojects (Study 1 and Study 2). In Study 1, the investigators will compare the effects of OXT on fear extinction and fear recall as well as on emotion recognition between wo...
Eligibility Criteria
Inclusion
- right handed
- healthy male \& female volunteers
- women will be tested in their follicular phase (Day 0-5)
Exclusion
- smoking
- pregnancy
- hormonal contraception
- current psychiatric illness
- current psychiatric medication or psychotherapy
- Study 2: MRI contraindication (e.g. metal in body, claustrophobia)
Key Trial Info
Start Date :
September 18 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 25 2020
Estimated Enrollment :
487 Patients enrolled
Trial Details
Trial ID
NCT04330677
Start Date
September 18 2016
End Date
January 25 2020
Last Update
April 7 2020
Active Locations (1)
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1
Deparment of Psychiatry and Medical Psychology
Bonn, Germany, 53105