Status:
UNKNOWN
Physiopathology of Neuromuscular Function Related to Fatigue in Chronic Renal Disease
Lead Sponsor:
Centre Hospitalier le Mans
Collaborating Sponsors:
Le Mans Universite
Conditions:
Chronic Kidney Disease Stage 3B
Chronic Kidney Disease stage4
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Chronic Kidney Disease (CKD) induces many metabolic troubles especially for the advanced CKD (stage 3b-5) patients and their prevalence and importance grow with the deterioration of the glomerular fil...
Eligibility Criteria
Inclusion
- Adults, aged 60 and over
- Social security coverage
- Signed informed consent
- For patient with Chronic Kidney Disease, estimated glomerular filtration rate (eGFR) less than 45ml/min/1.73m2 (Stage 3b) for at least 3 months
- For patient with Chronic Kidney Disease, stable clinical condition (i.e., Creatinine increased by a maximum of 25% in the previous 3 months)
- For control group, 1:1 recruitment with case matching with CDK patients on gender (i.e., male and female) and the presence of diabètes (i.e., presence and absence)
- For control group, blood test with control of renal function available and dated less than 6 months: with eGFR \> 60ml/min/1.73m2 (and control of glucose or glycated hemoglobin for diabetic controls)
Exclusion
- Pregnant women
- Under guardianship or minor
- Neuromuscular disease
- Dementia
- Upper limbs history of surgery or pathologies preventing from fitting EMG electrodes or measuring handgrip force
- Life expectancy of less than 3 months estimated by medical judgment
- Programed hospitalization in the previous 3 months
- Participation to another interventional clinical trial
- Acute kidney disease
- On dialysis or expected start of dialysis within next 3 months
Key Trial Info
Start Date :
June 22 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2022
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT04330807
Start Date
June 22 2020
End Date
June 1 2022
Last Update
March 23 2022
Active Locations (1)
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1
Centre Hospitalier Du Mans
Le Mans, France, 72000