Status:
UNKNOWN
The Genomic Medicine at VA Study
Lead Sponsor:
Boston VA Research Institute, Inc.
Collaborating Sponsors:
VA Boston Healthcare System
Conditions:
Coronary Artery Disease
Atrial Fibrillation
Eligibility:
All Genders
50-70 years
Phase:
NA
Brief Summary
This trial will determine the clinical effectiveness of polygenic risk score testing among patients at high genetic risk for at least one of six diseases (coronary artery disease, atrial fibrillation,...
Detailed Description
One of the most pressing controversies in genomics today is the clinical utility of polygenic risk scores (PRS). Broadening the scope of genomic risk testing beyond monogenic diseases, PRS combine inf...
Eligibility Criteria
Inclusion
- Age 50-70 years at enrollment
- No known diagnosis of the following conditions, initially screened by the International Classification of Disease (ICD) codes or other electronic health record (EHR) data using validated methods and then confirmed with potential patient-participants during recruitment: coronary artery disease, atrial fibrillation, type 2 diabetes, colorectal cancer, breast cancer, prostate cancer
Exclusion
- Patients will be ineligible if they:
- Have a known diagnosis of at least one of the six diseases of interest
- Are younger than age 50 or older than age 70
- Are pregnant
- Are incarcerated or institutionalized
Key Trial Info
Start Date :
July 17 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
1076 Patients enrolled
Trial Details
Trial ID
NCT04331535
Start Date
July 17 2020
End Date
September 30 2025
Last Update
October 3 2022
Active Locations (1)
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1
VA Boston Healthcare System
Boston, Massachusetts, United States, 02130-4817