Status:
WITHDRAWN
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
Lead Sponsor:
The University of Texas Medical Branch, Galveston
Conditions:
Eye Diseases
Ophthalmic Trauma
Eligibility:
All Genders
20-100 years
Brief Summary
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or diseas...
Detailed Description
The study aim to test correlation between the presence of the mitochondrial DNA in vitreous fluid and blood in patients that are admitted to UTMB's Eye clinic. The goal of the study is to analyze 4 gr...
Eligibility Criteria
Inclusion
- a) Target group
- Age ≥ 20 years old
- Subjects must not be nursing, pregnant or planning to become pregnant. Subjects of child bearing potential must have a documented negative pregnancy test at the time of preoperative assessment or not be of child bearing potential. Identified eye disease including but not limited to age-related macular degeneration, glaucoma and/or diabetic retinopathy.
- Scheduled ophthalmic surgery with expected vitreal humor discard.
- Subject has provided written informed consent to participate in this protocol. b) Control group
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- Age ≥ 20 years old
- Subjects must not be nursing, pregnant or planning to become pregnant. Subjects of child bearing potential must have a documented negative pregnancy test at the time of preoperative assessment or not be of child bearing potential.
- Lack of identified eye disease.
- Scheduled ophthalmic surgery with expected vitreal humor discard.
- Subject has provided written informed consent to participate in this protocol.
Exclusion
- a) Target group
- Age \< 20 years old
- Subject is nursing, pregnant, planning to become pregnant or of child bearing potential and does not agree to the use of reliable method of contraception during their participation in the study. A pregnancy test must be administered to women of childbearing potential at the time of preoperative assessment.
- Identified eye disease including but not limited to age-related macular degeneration, glaucoma and/or diabetic retinopathy.
- Subject has not completed informed consent to participate in this protocol. b) Scheduled ophthalmic surgery with expected vitreal humor discard Control group
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- Age \< 20 years old
- Subject is nursing, pregnant, planning to become pregnant or of child bearing potential and does not agree to the use of reliable method of contraception during their participation in the study. A pregnancy test must be administered to women of childbearing potential at the time of preoperative assessment.
- Lack of identified eye disease.
- Subject has not completed informed consent to participate in this protocol. Scheduled ophthalmic surgery with expected vitreal humor discard.
Key Trial Info
Start Date :
February 21 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 7 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04334499
Start Date
February 21 2020
End Date
December 7 2022
Last Update
March 23 2023
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