Status:
UNKNOWN
Effect of Ginkgo Biloba Capsule on Visual Function of Primary Open-angle Glaucoma With Blood Stasis Syndrome
Lead Sponsor:
Zhongshan Ophthalmic Center, Sun Yat-sen University
Conditions:
Primary Open Angle Glaucoma
Drug Effect
Eligibility:
All Genders
30-65 years
Phase:
NA
Brief Summary
Primary Open Angle Glaucoma (POAG) is an eye disease that causes optic nerve damage, visual field defect, and blindness caused by increased intraocular pressure. In recent years, many studies have sho...
Detailed Description
In this clinical study, the visual field, including MD, MS, LV, and vision score, are the main efficacy indicators. HRT and visual electrophysiological examination are the secondary efficacy indicator...
Eligibility Criteria
Inclusion
- 1\. Accord with the diagnostic criteria of primary open-angle glaucoma.
- 2\. Accord with the standard of blood stasis and collateralization syndrome in traditional Chinese medicine (TCM).
- 3\. Intraocular pressure ≤ 18mmHg
- 4\. AGIS score of visual field defect ≥ 6 points and ≤ 17 points, cup to disc ratio \> 0.6, central corrected visual acuity ≥ 0.3.
Exclusion
- 1\. The diagnoses of angle closure glaucoma, absolute glaucoma, glaucoma ciliary body syndrome, high intraocular pressure (IOP) and secondary glaucoma.
- 2\. Patients with various fundus diseases, such as retinal detachment, retinal vein occlusion, retinal pigmented degeneration, blood or vascular diseases.
- 3\. Complicated with cornea, iris, visible lens lesion, or one-eye patient.
- 4\. Patients who need to use improved circulation, nutritional nerve drugs during the trial.
- 5\. Any eye surgery or laser therapy during the induction period.
- 6\. Patients with a history of eye infection during the introduction period.
- 7\. Complicated with severe liver and kidney diseases, or abnormal examination of liver and kidney function (ALT,AST ≥ normal upper limit 1.5 times, SCr \> normal upper limit).
- 8\. Complicated with severe heart and lung diseases (such as bronchial asthma or history of bronchial asthma, chronic obstructive pulmonary disease, bronchospasm, respiratory failure, etc.), diabetes, advanced tumors, blood and hematopoietic system diseases, or other serious or progressive diseases of the system.
- 9\. A person who is prone to bleeding, or who has suffered severe bleeding during the period of introduction.
- 10\. Pregnant, lactating women or recent birth plans.
- 11\. Other conditions considered inappropriate by the investigator.
- 12\. Patients who participated in other clinical trials during the introduction period.
Key Trial Info
Start Date :
April 28 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2020
Estimated Enrollment :
512 Patients enrolled
Trial Details
Trial ID
NCT04334564
Start Date
April 28 2015
End Date
November 30 2020
Last Update
April 6 2020
Active Locations (1)
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1
Zhognshan Ophthalmic Center, Sun Yat-sen University
Guangzhou, Guangdong, China, 510060