Status:
COMPLETED
Use of a Respiratory Multiplex PCR and Procalcitonin to Reduce Antibiotics Exposure in Patients With Severe Confirmed COVID-19 Pneumonia
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
BioMérieux
Conditions:
Covid19
Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The novel coronavirus SARS-CoV-2 (COVID-19) is an emerging respiratory virus that causes pneumonia. WHO data reported admission to the intensive care unit (ICU) for 6% of patients, with a mortality ra...
Detailed Description
Inclusion (D0\_H0) is performed in ICU as soon as possible, once the diagnosis of COVID-19 pneumonia is confirmed. Therefore, inclusion might be performed either on ICU admission (if the COVID-19 pneu...
Eligibility Criteria
Inclusion
- Adults (\>= 18 years) admitted to the ICU;
- Severe confirmed COVID-19 pneumonia, defined by i) a newly-appeared pulmonary parenchymal infiltrate; and ii) a positive RT-PCR (either upper or lower respiratory tract) for COVID-19 (SARS-CoV-2); iii) and admission to the ICU or intermediate care unit;
- Informed consent or emergency procedure.
Exclusion
- Pregnancy ;
- Congenital immunodeficiency;
- HIV infection with CD4 count below 200/mm3 or unknown in the last year;
- High-grade hematological malignancy;
- Neutropenia (\<1 leucocyte/mL or \< 0.5 neutrophil/mL);
- Immunosuppressive drugs within the previous 30 days, including anti-cancer cytotoxic chemotherapy and anti-rejection drugs for organ/bone marrow transplant;
- Moribund patient or death expected from underlying disease during the current admission;
- Patient deprived of liberty or under legal protection measure
Key Trial Info
Start Date :
April 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 23 2021
Estimated Enrollment :
194 Patients enrolled
Trial Details
Trial ID
NCT04334850
Start Date
April 20 2020
End Date
June 23 2021
Last Update
August 3 2021
Active Locations (1)
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1
Intensive care department-Hospital Tenon
Paris, France, 75020