Status:
UNKNOWN
Terlipressin for Refractory Septic Shock
Lead Sponsor:
Mahidol University
Conditions:
Septic Shock
Refractory Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Norepinephrine was recommended as the first vasopressor for septic shock resuscitation. For the patient who did not response to high dose norepinephrine, epinephrine was recommended. Vasopressin was...
Detailed Description
Norepinephrine was recommended as the first vasopressor for septic shock resuscitation. For the patient who did not response to high dose norepinephrine, epinephrine was recommended. Both norepineph...
Eligibility Criteria
Inclusion
- Septic shock according to Sepsis-3 definition
- Evidence of adequate fluid
- Received norepinephrine 0.2 mcg/kg/min or more
- Received norepinephrine plus epinephrine (any dose)
- Mean arterial lower than 65 mmHg or lactate \> 2 mmol/liter
Exclusion
- Septic shock diagnosis \> 48 hours before
- Receive intravenous fluid \< 30 mL/kg before enrollment
- Do-not-resuscitation and terminally ill
- Refractory to treatment malignancy
- Pregnancy
- 7\. Chronic renal failure stage 5 with no plan for long term renal replacement therapy 8. Cirrhosis child C 9. Cardiogenic shock 10. Acute decompensated heart failure 11. Evidence of left ventricular ejection fraction (LVEF) \< 35% 12. Acute coronary syndrome within 72 hours 13. Severe valvular heart disease 14. Documented life-threatening tachyarrhythmia before enrollment 15. Diagnosis of acute mesenteric ischemia before enrollment 16. Previous diagnosis of Raynaud's phenomenon 17. Known peripheral arterial disease 18. Refuse to sign the informed consent by patient or representative
Key Trial Info
Start Date :
April 3 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2025
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04339868
Start Date
April 3 2020
End Date
July 31 2025
Last Update
September 24 2021
Active Locations (1)
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1
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700