Status:
WITHDRAWN
Early Versus Late ECMO Therapy in COVID-19 Induced ARDS (ECMO-VID)
Lead Sponsor:
University Hospital Tuebingen
Collaborating Sponsors:
University Hospital Freiburg
RWTH Aachen University
Conditions:
ARDS, Human
COVID-19
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Experimental intervention: Insertion of Extracorporal Membrane Oxygenation (ECMO) within 24 hours of referral to an Intensive Care Unit. Control intervention: Insertion of Extracorporal Membrane Oxyg...
Detailed Description
The severe form of COVID-19 infection is characterized and marked by severe pneumonia and the Acute Respiratory Distress Syndrome (ARDS). ARDS is characterized by the loss of pulmonary tissue complian...
Eligibility Criteria
Inclusion
- COVID-19positive(+) ARDS as defined according to the Berlin Definition
- ratio of partial pressure arterial oxygen and fraction of inspired oxygen (PaO2/ FiO2) ≤100
- Bilateral opacities consistent with pulmonary edema on frontal chest radiograph
- requirement for positive pressure ventilation via an endotracheal tube or non-invasive ventilation
- no clinical evidence of left atrial hypertension, or if measured, a Pulmonary Arterial Wedge Pressure (PAOP) less than or equal to 18 mmHg.
- ≤ 7 days from the initiation of mechanical ventilation at the time of randomization. - Patients must be enrolled within 96 hours of onset of ARDS -
Exclusion
- COVID-19negative(-) ARDS
- Age less than 18 years
- More than 7 days since initiation of mechanical ventilation
- more than 96 hours since meeting ARDS criteria
- patient, surrogate or physician not committed to full intensive care support.
- pregnancy
Key Trial Info
Start Date :
August 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04341285
Start Date
August 1 2020
End Date
May 1 2022
Last Update
June 9 2021
Active Locations (1)
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1
University Hospital Tuebingen
Tübingen, Germany, 72076