Status:
UNKNOWN
Amisulpride Treatment for BPSD in AD Patients
Lead Sponsor:
Tianjin Anding Hospital
Conditions:
BPSD
Amisulpride
Eligibility:
All Genders
Phase:
NA
Brief Summary
Currently, olanzapine is the most widely used and studied drug for the treatment of behavioral and psychological symptoms in patients with Alzheimer's disease, but there are significant side effects. ...
Detailed Description
This study was a randomized, open-label, prospective clinical study in which patients were randomized to receive amisulpride and olanzapine for 8 weeks. Drug efficacy and safety assessments were asses...
Eligibility Criteria
Inclusion
- It conforms to the diagnostic standard of Alzheimer's disease in International Classification of Diseases 10th Revision (ICD-10)
- a total score of MMSE\<24
- The patients had active behavioral symptoms with a minimum score of 20 on the 12-point Neuropsychiatric Inventory (NPI)
- Participant or guardian has to sign informed consent. The patients' guardians will sign the informed consent on behalf of the participants when the capacity of participants to consent is compromised
Exclusion
- People with vascular dementia, frontotemporal dementia, dementia with Lewy bodies or other neurocognitive disorders;
- Patients with severe brain organic diseases or brain trauma;
- Physical illnesses associated with severe respiratory, circulatory, immune, and endocrine systems;
- History of other mental disorders;
- Those who are allergic to amisulpride or olanzapine;
- Patients who are contraindicated with amisulpride and olanzapine: pheochromocytoma, prolactin-dependent tumors and narrow-angle glaucoma;
Key Trial Info
Start Date :
December 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2024
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT04341467
Start Date
December 1 2019
End Date
May 1 2024
Last Update
November 16 2022
Active Locations (1)
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1
Tianjin Anding Hospital
Tianjin, Tianjin Municipality, China, 300222