Status:
COMPLETED
Intraoperative Infusion of Methylene Blue for Prevention of Postoperative Delirium and Cognitive Dysfunction in Elderly Patients Undergoing Major Elective Noncardiac Surgery
Lead Sponsor:
Fudan University
Conditions:
Postoperative Delirium
Postoperative Cognitive Dysfunction
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
Postoperative neurocognitive impairments often occur in elderly patients undergoing anesthesia and non-cardiac surgery, including postoperative delirium (POD) and postoperative cognitive dysfunction (...
Detailed Description
Postoperative neurocognitive impairments often occur in elderly patients undergoing major surgery, including postoperative delirium(POD) characterized by an acute change in cognition with altered cons...
Eligibility Criteria
Inclusion
- aged 60-80 years old
- planning to undergo non-cardiac and non-neurosurgical surgery (e.g..thoracic, orthopaedic, urologic and major abdominal surgeries) under general anesthesia
- MMSE\>20
- Liver and kidney function are normal
- Patients have the ability to act in full spirit, understand and sign the informed consent, and are willing to complete the whole research process.
Exclusion
- Patients with personal history of allergy to methylene blue
- Emergency Surgery
- Patients have 6-phospho-glucose dehydrogenase deficiency (vicia faba disease)
- Patients have recent drug administration that may lead to drug interactions(e.g..SSRIs, SNRIs)
- Patient with a history of major head trauma
- Patients with a history of drug or alcohol abuse
- Patient has serious mental or neurological disorders
- Patients with severe language, hearing and visual impairment
- Patients have serious medical diseases(e.g..heart failure, acute stage of myocardial infarction or respiratory failure)
- Illiteracy
- Patients have participated in other clinical trials in the last 3 months.
Key Trial Info
Start Date :
January 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2020
Estimated Enrollment :
248 Patients enrolled
Trial Details
Trial ID
NCT04341844
Start Date
January 14 2019
End Date
July 30 2020
Last Update
October 27 2020
Active Locations (1)
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1
Huashan Hospital
Shanghai, Shanghai Municipality, China, 200040