Status:
UNKNOWN
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Lead Sponsor:
Turku University Hospital
Conditions:
Morbid Obesity
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is ...
Detailed Description
This is a prospective study, where subjects for the morbidly obese group (N=60) will be recruited from the patients undergoing bariatric surgery according to normal treatment protocol and the bariatri...
Eligibility Criteria
Inclusion
- For the morbidly obese subjects:
- BMI 35.0-45.0 kg/m2, or BMI 32.0-45.0 kg/m2 and diagnosed diabetes
- Eligible to bariatric surgery evaluated according to normal treatment paradigm
Exclusion
- Metal objects in the body (including pacemakers, metallic artificial valve prostheses, inner ear implants, surgical clips, braces, foreign fragments)
- Previous participation in PET studies
- Pregnancy
- Poor compliance, alcohol or drug abuse
- Weight over 150 kg or waist circumference over 150 cm
- Diabetes with fasting glucose levels ≥7.0 mmol/L, or treatment with insulin
- Any chronic disease, medication or condition that could create a hazard to subject safety, endanger study procedures or interfere with the interpretation of results.
- For the lean control subjects:
- Inclusion Criteria:
- BMI 18-27 kg/m2
- Fasting plasma glucose ≤6.1 mmol/L
- Normal values in 2-hour oral glucose tolerance test
Key Trial Info
Start Date :
February 11 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2022
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04343469
Start Date
February 11 2019
End Date
September 1 2022
Last Update
October 13 2021
Active Locations (2)
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1
Turku PET Centre
Turku, Finland, 20520
2
Turku University Hospital
Turku, Finland, 20520