Status:
NOT_YET_RECRUITING
Impact of T Cells on Age-related Vascular Dysfunction: A Translational Approach
Lead Sponsor:
University of Utah
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Cardiovascular Diseases
Inflammation
Eligibility:
All Genders
55-75 years
Phase:
EARLY_PHASE1
Brief Summary
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States and other industrialized societies, and advanced age is the major risk factor for development of CVD. ...
Detailed Description
Advanced age is the primary and most predictive risk factor for CVD. The investigators have demonstrated that there is a pronounced age-associated increase in T cell infiltration into the perivascular...
Eligibility Criteria
Inclusion
- Older adults (55-75 years old).
- Women will be at least two years postmenopausal, not using hormone therapy and have a follicle stimulating hormone (FSH) concentration of \>30 IU/L.
Exclusion
- Autoimmune disorders,
- Hypertension (blood pressure \>140/90mmHg),
- Body mass index of \>30 kg/m2,
- Clinical CVD,
- Diabetes
- Current tobacco use,
- Regular aerobic exercise (\>30 mins per day, \> 2 days per week for the at least the last 2 years),
- Current or recurring infections within 12 weeks of the baseline visit,
- A positive tuberculosis (TB) test or subjects at risk of TB,
- Positive test for Hepatitis B, C, or cytomegalovirus (CMV),
- Use of immunosuppressive medication,
- Vaccination within 4 weeks of the baseline visit,
- Major surgery within 8 weeks of the baseline visit,
- Previous lymphoid irradiation or bone marrow transplant,
- Subjects at risk for diverticulitis,
- Any laboratory test result that, in the opinion of the overseeing physician (Dr. Frech) might place a participant at unacceptable risk.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04344873
Start Date
September 1 2025
End Date
November 1 2026
Last Update
April 3 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.