Status:
RECRUITING
Magnetic Resonance Imaging (MRI) With Hyperpolarized Pyruvate (13C) as Diagnostic Tool in Advanced Prostate Cancer
Lead Sponsor:
Ivan de Kouchkovsky, MD
Collaborating Sponsors:
National Cancer Institute (NCI)
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Conditions:
Prostate Cancer
Advanced Prostate Carcinoma
Eligibility:
MALE
18+ years
Phase:
PHASE2
Brief Summary
This is a prospective imaging study evaluating the utility of baseline metabolic MR imaging as a diagnostic and response monitoring tool in patients with advanced prostate cancer. Preliminary pre-clin...
Detailed Description
PRIMARY OBJECTIVES: I. To determine the kPL (metabolic flux from hyperpolarized \[HP\] \[1-13C\]pyruvate to \[1-13C\]lactate) and kPG (metabolic flux from HP \[2-13C\]pyruvate to \[5-13C\]glutamate) ...
Eligibility Criteria
Inclusion
- Histologically-confirmed locally advanced or metastatic prostate cancer. Patients with unequivocal clinical evidence supporting diagnosis of prostate cancer who have not had prior biopsy may be considered eligible per judgment of Principal Investigator.
- Presence of at least one target lesion detected by standard staging scans that, in the judgment of Study Investigators, would be amenable to hyperpolarized C-13 pyruvate/metabolic MR imaging:
- Soft tissue/visceral organ target lesions must measure at 1 cm in long axis diameter on CT or MRI.
- Target lesions in the bone must be visualized by CT or MRI (lesions present only on bone scan do not qualify).
- For patients with target lesion in prostate/prostatic bed:
- i. No contra-indications to endorectal coil insertion (e.g., patients with a prior abdominoperineal resection of the rectum or latex allergy).
- ii. No prior local treatment to the selected lesion, or evidence of radiographic progression following prior local therapy to selected lesion.
- Able and willing to comply with study procedures and provide signed and dated informed consent.
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1
- For patients undergoing optional tumor biopsy:
- No history of bleeding diathesis.
- Patients on anti-coagulation they must be able to safely stop treatment for purposes of tumor biopsy.
Exclusion
- Patients who because of age, general medical or psychiatric condition, or physiologic status cannot give valid informed consent.
- Patients unwilling or unable to undergo MR imaging, including patients with contra- indications to MRI, such as cardiac pacemakers or non-compatible intracranial vascular clips.
- Metallic hip implant or any other metallic implant or device that distorts local magnetic field and compromises the quality of MRI.
- Any condition that, in the opinion of the Principal Investigator, would impair the patient's ability to comply with study procedures
Key Trial Info
Start Date :
July 16 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2026
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT04346225
Start Date
July 16 2020
End Date
November 30 2026
Last Update
July 3 2024
Active Locations (1)
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1
University of California, San Francisco
San Francisco, California, United States, 94143