Status:
COMPLETED
Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
Lead Sponsor:
Duke University
Conditions:
COVID-19
Eligibility:
All Genders
18+ years
Brief Summary
This current proposal evaluates the Longitudinal Energy Expenditure and Metabolic Effects in Patients with COVID-19 (LEEP-COVID) to understand, guide and optimize our metabolic and nutritional care of...
Detailed Description
Currently, no longitudinal data exist describing the metabolic and cardiac effects of SARS-CoV-2 (COVID-19) infection. This data is urgently needed to assist in care and promote recovery of COVID-19 p...
Eligibility Criteria
Inclusion
- Critically ill COVID-19 patients greater or equal to 18 years of age patients requiring mechanical ventilation for \> 48 hours who are admitted to Duke Surgical/Trauma ICU, Medical ICU, Cardiothoracic ICU, and Neuro ICU from admission to hospital discharge
- Patients must be enrolled within 72 hours of ICU admission
- Control: non-COVID-19 respiratory failure patients requiring mechanical ventilation \> 48 h receiving similar ICU standards of care at Duke
Exclusion
- Age less than 18 years old
- Fraction of inhaled oxygen (FIO2) \> 70%
- Positive end expiratory pressure (PEEP) \> 10cmH2O
- Peak ventilatory pressure \> 30cmH20
- Presence of air leaks from thoracic drain tube
- Changes in vasoactive agent dose (\>20%, \<1 hr before or during IC)
- Agitation or change in sedative/analgesic dose (\>20%, \<1 hr before and/or during IC)
- Change in body temperature (\>0.5°C, \<1 hr before and/or during IC)
- Expected duration of ICU stay \< 24 hours
- Expected survival of the patient \< 24 hours
Key Trial Info
Start Date :
April 20 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 22 2022
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT04350073
Start Date
April 20 2020
End Date
August 22 2022
Last Update
May 16 2023
Active Locations (1)
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1
Duke University Medial Center
Durham, North Carolina, United States, 27710