Status:
UNKNOWN
Bone Marrow Versus Adipose Autologous Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis
Lead Sponsor:
Universidad Catolica Santiago de Guayaquil
Collaborating Sponsors:
Maastricht University Medical Center
Conditions:
Osteo Arthritis Knee
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
Mesenchymal stem cells (MSC) are stromal cells that have the ability to self-renew and also exhibit multilineage differentiation. MSCs can be isolated from a variety of tissues, such as umbilical cord...
Detailed Description
The aim of the present study will be to compare 3 types of intra-articular injections of MSC populations obtained from two clinically relevant sources: injections containing BM-MSC or AD-MSC or a comb...
Eligibility Criteria
Inclusion
- Patients aged 18 to 70 years, with grade II and III knee OA, according to the Ahlbäck classification will be included.
- Minimal VAS pain score of 4.
- Chronic knee pain of mechanical origin.
- All patients who sign a specially prepared informed consent for this clinical trial.
Exclusion
- Varus or valgus knee mal alignment superior to 10°.
- OA grade IV according Ahlbäck classification.
- Bone marrow cancer like lymphoma.
- Severe anemia.
- Active infections.
- Pregnant patients.
- Inmune diseases such as Rheumatoid arthritis, gout or pseudogout arthritis, psoriasis.
- Bone diseases such as Kahler and Paget.
- Corticoesteroid and hyaluronic injections within the last 3 months.
- Knee surgery in the last 6 months.
Key Trial Info
Start Date :
June 7 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 7 2021
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT04351932
Start Date
June 7 2020
End Date
September 7 2021
Last Update
April 17 2020
Active Locations (1)
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1
Omnihospital
Guayaquil, Guayas, Ecuador, 9018