Status:
COMPLETED
Immunologic Features of Respiratory Failure in Pediatric Hematopoietic Cell Transplantation (HCT) Recipients and Pediatric Oncology Patients
Lead Sponsor:
St. Jude Children's Research Hospital
Conditions:
Respiratory Failure
Respiratory Disease
Eligibility:
All Genders
Up to 21 years
Brief Summary
This study is being done because researchers want to learn more about genes that control the immune response in the participant's lungs and blood when the participant have lung disease leading to resp...
Detailed Description
This study involves a Tracheal aspirate, Bronchoalveolar lavage (BAL), and blood samples. The tracheal aspirates and blood samples will be obtained within 24 hours of intubation, then twice more every...
Eligibility Criteria
Inclusion
- Participant is age 0 to 21 years old
- Participant has acute respiratory failure due to primary pulmonary disease and is expected to receive invasive mechanical ventilation for more than 48 hours
Exclusion
- The primary etiology of respiratory failure is not related to primary pulmonary disease
- Aspiration is present
- The participant has a tracheostomy
- If the patient has undergone HCT, they are more than 100 days removed from HCT
- Has a diagnosis of severe combined immunodeficiency syndrome (SCIDS)
- The primary on-service team feels obtaining a study sample would be unsafe for any reason.
- Inability or unwillingness of research participant or legal guardian/representative to give written informed consent.
Key Trial Info
Start Date :
January 8 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 30 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04355780
Start Date
January 8 2021
End Date
August 30 2023
Last Update
September 8 2023
Active Locations (1)
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1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105