Status:
UNKNOWN
COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1
Lead Sponsor:
Dr Gerry Gin Wai Kwok
Collaborating Sponsors:
The University of Hong Kong
Conditions:
COVID-19
SARS-CoV-2
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This is an open-label, controlled, single-centre pilot study of nivolumab in adult patients with COVID-19. This clinical study aims to evaluate efficacy of anti-PD1 antibody in relation to viral clear...
Eligibility Criteria
Inclusion
- Diagnosis of COVID-19 by RT-PCR for SARS-CoV-2
- Clinically stable with disease severity defined as mild or moderate (mild disease is defined as symptoms with or without lung infiltrates on chest X-Ray or CT imaging; moderate disease is defined as lung infiltrates with evidence of type 1 respiratory failure)
- Asymptomatic patients may be enrolled if patients have obvious radiographic changes on chest or CT radiography deemed to be related to COVID-19
Exclusion
- Active cancer, rheumatological and autoimmune conditions
- Transplant recipients, or patients on active immunosuppressants
- Chronic organ impairment, or documented or suspected concomitant infections (including chronic viral hepatitis B and hepatitis C) other than SARS-CoV-2
- Lactating mothers and women who are pregnant or intending to become pregnant
- Acute respiratory distress syndrome, evidence of myocardial injury, disseminated intravascular coagulopathy, organ failure, hemophagocytosis, shock, respiratory distress, or need for mechanical ventilation, AICU admission, or high flow oxygen therapy
Key Trial Info
Start Date :
April 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2021
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04356508
Start Date
April 14 2020
End Date
August 31 2021
Last Update
April 22 2020
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