Status:
UNKNOWN
The Combination of Sintilimab and AI (Doxorubicin, ADM/Ifosfamide, IFO) for the First Line Treatment of Select Type of Metastatic/Unresectable Soft Tissue Sarcoma
Lead Sponsor:
Fudan University
Collaborating Sponsors:
Zhejiang Cancer Hospital
Tongji Hospital
Conditions:
Sarcoma, Soft Tissue
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
Brief Summary
This is a phase II trial to explore the feasibility of PD-1 immune check point inhibitor, sintilimab, in combination of stand of care chemotherapy in first-line treatment of selected soft tissue sarco...
Eligibility Criteria
Inclusion
- Men and women aged 18-75 years;
- Provide written informed consent;
- Local advanced or metastatic unresectable sarcoma;
- Histologically confirmed undifferentiated pleomorphic sarcoma, synovial sarcoma, de-differentiated liposarcoma and myxoid liposarcoma;
- Performance status of 0 to 1 on the Eastern Cooperative Oncology Group (ECOG) performance scale;
- Have measurable disease based on Response Evaluation Criteria in Solid Tumors (RECIST) 1.1;
- Life span expectation over 3 months
- Absolute neutrophil count (ANC) ≥1,500/mcL (within 7 days of treatment initiation) ；
- Hemoglobin ≥9 g/dL (within 7 days of treatment initiation) ；
- Platelets ≥ 90,000/mcL (within 7 days of treatment initiation) ；
- Serum creatinine ≤ 1.5 X upper limit of normal (ULN) or creatinine clearance \[CrCl\]) ≥ 50 mL/min for subject with creatinine levels (within 7 days of treatment initiation) ；
- Serum total bilirubin ≤ 1.5 X ULN (within 7 days of treatment initiation) ；
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) ≤ 2.5 X ULN or =\< 5 X ULN for subjects with liver metastases (within 7 days of treatment initiation)；
Exclusion
- Prior systemic therapy for advanced and metastatic disease, except adjuvant treatment（not received anthracycline）replase over 6 months;
- Received any testing anti-cancer drugs within four weeks of treatment initiation;
- Prior immune related therapy including but not limited to PD-1, PD-L1, CD137, CTLA4, T cell stimulation, check point inhibitor etc;
- Symptomatic, untreated, or uncontrolled brain metastases present
- clinical meaningful active bleeding;
- Other malignant cancer history rather than soft tissue sarcoma within five year prior to treatment initiation;
- Have active infections requiring therapy;
- Have active autoimmune disease or a documented history of autoimmune disease or syndrome that requires systemic steroids or immunosuppressive agents. Patients that require inhaled steroids or local steroid injections would not be excluded from the study. Patients with hypothyroidism not from autoimmune disease that is stable on hormone replacement will not be excluded from the study.
- Pregnant or breast-feeding；
- Any serious or unstable medical condition or mental illness；
- Serious systemic diseases such as heart disease, history of (non-infectious) pneumonitis;
- Active HBV （\>10000 copy/ml） and HCV （RNA\> 1000copy/ml） infection；
- Positive human immunodeficiency virus (HIV）or any acquired immunodeficiency syndrome, organ implantation;
Key Trial Info
Start Date :
April 8 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 30 2023
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04356872
Start Date
April 8 2020
End Date
March 30 2023
Last Update
July 14 2020
Active Locations (1)
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1
Fudan University, Cancer Hospital
Shanghai, Shanghai Municipality, China, 200000