Status:
UNKNOWN
Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19
Lead Sponsor:
Ain Shams University
Conditions:
Coronavirus Disease (COVID-19)
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This randomized open labeled clinical trial will include one hundred healthy healthcare workers who will be randomly assigned into four groups of twenty-five each to receive either levamisole, Isoprin...
Detailed Description
One hundred healthy health workers will be randomly assigned to receive either Levamisole, Isoprinosine, Levamisole and Isoprinosine or no-intervention for two months. Written informed consent will be...
Eligibility Criteria
Inclusion
- Adult \> 18 years old
- Both Gender (male and female)
- Healthy health care workers employed by one of the hospitals involved in the study
- Negative serology at day 0 for COVID19 infection.
- Evidence of a personally signed and dated informed consent document
Exclusion
- Participations in other investigational clinical trials for the treatment or prevention of SARS-COV-2 infection
- Previous or recent COVID 19 infection (previously had a SARS-CoV-2 positive test result or confirmed case of SARS-CoV-2 infection or positive serology at day 0)
- Any medical illness
- Has a congenital immunodeficiency, including specific deficiencies of the interferon-gamma pathway
- Participants receiving steroids, cytotoxic immunosuppressive agents, radiotherapy.
- Participants who have received any other immunotherapy.
- Participants with a history of gout, urolithiasis, nephrolithiasis, renal dysfunction and severe gastric ulcer.
- Participants receiving allopurinol, indomethacin, colchicine or diuretics.
- Participants with hematological problems.
- Known hypersensitivity reactions or Wheat Allergy
- Pregnant and lactating females.
- Refusal to sign the informed consent form
- Refusal of participation
Key Trial Info
Start Date :
May 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04360122
Start Date
May 20 2020
End Date
December 1 2020
Last Update
May 5 2020
Active Locations (1)
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1
Faculty of Medicine Ain Shams University Research Institute- Clinical Research Center
Cairo, Non-US, Egypt, 11566