Status:
UNKNOWN
Exercise Therapy for Osteoarthritis Pain: How Does it Work?
Lead Sponsor:
Vrije Universiteit Brussel
Collaborating Sponsors:
Universitair Ziekenhuis Brussel
AZ St.-Dimpna Geel
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
International guidelines recommend exercise as the first choice treatment for knee osteoarthritis (KOA). Muscle strengthening training (MST) and behavioural graded activity (BGA) show comparable effec...
Eligibility Criteria
Inclusion
- KOA according to the clinical American College of Rheumatology (ACR) criteria. The clinical ACR criteria for KOA are: knee pain and at least 3 of the 6 following features: age ≥50, morning stiffness \<30 minutes, crepitus, bony tenderness, bony enlargement, no palpable warmth. KOA will be confirmed with radiographs, including anterior-posterior (AP) and medio-lateral (ML) radiographs for imaging the tibiofemoral joint, and an axial view for imaging the patellofemoral joint. Kellgren and Lawrence (K\&L) grading system for OA will be applied, with K\&L grade 2 or higher defined as OA; radiographic KOA is defined as definite osteophytes and possible joint space narrowing.
- pain, nominated by the patient as 3 /10 or higher on a visual analogue scale on most days of the last 3 months
- aged ≥ 50 years.
Exclusion
- treatment with exercise therapy or joint infiltrations (e.g., corticosteroids, hyaluronic acid) in the preceding 6 months;
- being on a waiting list for knee replacement;
- any contra-indication for exercise therapy as established by the treating physician;
- corticosteroid infiltrations in the last 6 months;
- cognitive impairment (unable to understand the test instructions and/or Mini Mental State Examination score \<23/30);
- unable to understand the Dutch language;
- inflammation unrelated to OA (e.g. due to acute or chronic infection) established by CRP\>10mg/L.
- presence of a disorder and/or medication that influences pain and/or the immune system
Key Trial Info
Start Date :
March 5 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04362618
Start Date
March 5 2020
End Date
December 31 2023
Last Update
May 30 2023
Active Locations (1)
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1
Vrije Universiteit Brussel (VUB)
Jette, Brussels Capital, Belgium, 1090