Status:
UNKNOWN
Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive Unit
Lead Sponsor:
Nantes University Hospital
Conditions:
COVID-19 Pneumonia
Eligibility:
All Genders
18-99 years
Phase:
PHASE3
Brief Summary
The global pandemic of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in Wuhan, China, in December 2019, and has since spread wo...
Eligibility Criteria
Inclusion
- Adult ≥ 18 ans,
- Patient with positive SARS-CoV-2 RT-PCR on nasopharyngeal sample at randomization or within the previous 48 hours,
- Patient with pneumonia diagnosed by thorax CT-scan or echography,
- Patient able to take per os medication,
- Written and signed consent of the patient,
- Patients affiliated with or benefitting from a social security scheme.
Exclusion
- Patient hospitalized in intensive care unit,
- Patient who received more than 24 hours of antibiotic treatment for the ongoing episode,
- Chronic renal failure with a Glomerular Filtration Rate \< 20ml/min,
- Severe hepatic failure,
- Severe chronic cardiac insufficiency,
- Allergy to macrolides,
- Electrocardiogram showing corrected QT prolongation greater than 470 ms in men and 480 ms in women.
- Life-threatening presentation expected to lead to possible imminent death (based on provider assessment)
Key Trial Info
Start Date :
April 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2020
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT04363060
Start Date
April 30 2020
End Date
July 30 2020
Last Update
April 29 2020
Active Locations (3)
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1
Chu Angers
Angers, France
2
CHD Vendée
La Roche-sur-Yon, France
3
CHU Poitiers
Poitiers, France