Status:
COMPLETED
Endothelial Glycocalyx in Patients With Chronic Kidney Disease
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Healthy
Chronic Kidney Diseases
Eligibility:
All Genders
18+ years
Brief Summary
The luminal side of the entire vasculature is covered with a gel-like polymer called endothelial glycocalyx (EG). EG is important for the transport of molecules in and out of the blood cells and for e...
Detailed Description
The purpose of this study is to gain knowledge about how pronounced the EG are affected in varying degrees of chronic kidney disease compared with healthy controls assessed by 1. salt-blood test 2. r...
Eligibility Criteria
Inclusion
- Inclusion Criteria patients with chronic kidney disease:
- CKD I-V Age\> 18 years 4 diabetics in each CKD-class Dialysis patients must have received dialysis for at least 3 months. Signed consent
- Exclusion Criteria, patients with chronic kidney disease:
- Nephrotic syndrome (U-alb\> 3.5 g / d, p-alb \<30 g / l, and peripheral edema) Alcohol abuse Drug abuse Pregnancy and lactation Hbg \<6.2 mmol / l
- Inclusion criteria, healthy people:
- Both gender Signed consent
- Exclusion criteria, healthy people:
- Arterial hypertension heart, lung, liver, kidney, endocrine og cerebral diseases alcohol, drug or medical abuse smoking pregnancy or breastfeeding blood-donation within a month clinically significant abnormalities in ECG, blood samples or urine samples
Exclusion
Key Trial Info
Start Date :
November 7 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2019
Estimated Enrollment :
137 Patients enrolled
Trial Details
Trial ID
NCT04363567
Start Date
November 7 2016
End Date
December 1 2019
Last Update
April 27 2020
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