Status:
COMPLETED
Insights From the Retina on Cerebral Microvascular Dysfunction in Haemorrhagic Stroke
Lead Sponsor:
University of Zurich
Conditions:
Intracerebral Hemorrhage
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Fundoscopy, optical coherence tomography (OCT) and OCT-angiography (OCTA) are established examinations and bear minimal risks. The recognition of retinal microvascular signs will enhance the pathophys...
Detailed Description
The purpose of the study is to * To evaluate the feasibility of fundoscopy, OCT and OCTA imaging in the environment of a Neurocritical Care Unit (NCCU) * To detect, quantify and associate microvascul...
Eligibility Criteria
Inclusion
- All groups
- Primary ICH or aSAH with symptoms onset \< 3 days
- 18 to unlimited years of age
- Signed informed consent obtained from legal representative or patient ICH group
- Primary ICH localized either in basal ganglia, thalamus, pons or cerebellum aSAH group
- Ruptured aneurysm visualized in contrast-enhanced computed tomography (angio-CT), MRI or cerebral angiography Control group
- Stroke due to perimesencepahlic subarachnoid hemorrhage, arteriovenous malformation or isolated traumatic brain injury
Exclusion
- All groups
- Cerebral amyloid angiopathy or other neurodegenerative disease
- History of migraine with aura or ischemic stroke
- Contraindication for pupil dilation (intracranial hypertension, allergy against mydriatics, angle closure glaucoma)
- Any pre-existing or manifest ocular condition affecting either the integrity of retinal vessels, transparency of optical media or the risk of acute angle closure glaucoma
- Concomitant instable critical illness (e.g. sepsis, multi-organ failure)
- Intracranial pressure \> 20mmHg and refractory to cerebrospinal fluid drainage
- Pregnancy
Key Trial Info
Start Date :
February 23 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 28 2022
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04363619
Start Date
February 23 2021
End Date
July 28 2022
Last Update
August 4 2022
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland, CH-8091