Status:
COMPLETED
Muscle Stimulation for Physical Function During Stem Cell Transplant
Lead Sponsor:
VA Office of Research and Development
Conditions:
Autologous Hematopoietic Stem Cell Transplant
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Some blood, bone marrow, and lymphatic (hematologic) cancers such as Hodgkin/Non-Hodgkin lymphomas, chronic lymphocytic leukemia, and multiple myeloma, are over-represented in Veterans due to exposure...
Detailed Description
Hematopoietic cell transplantation (HCT) reduces physical function and muscle mass and increases fatigue. Neuromuscular electrical stimulation (NMES), when used as a stand-alone intervention, improves...
Eligibility Criteria
Inclusion
- adequate cognitive and language ability to provide consent
- Veteran enrolled in MTU at VAPSHCS for planned standard of care autologous HCT
Exclusion
- active deep vein thrombosis or thrombophlebitis
- untreated hemorrhagic disorders
- concomitant study inclusion in other nutritional or physical exercise interventional trials
- concomitant use of anabolic agents
- rhabdomyolysis or other muscle conditions where NMES is contraindicated
- implanted cardiac device
- baseline patient-reported muscle soreness of 5-6 on the soreness likert scale that is unrelated to recent physical exertion
- history of prior hematologic stem cell transplant
- probable or definitive liver cirrhosis
- reduced renal clearance defined as Stage 4 chronic kidney disease (glomerular filtration rate \<45 ml/min/1.73 m2)
Key Trial Info
Start Date :
May 14 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 29 2025
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04364256
Start Date
May 14 2021
End Date
December 29 2025
Last Update
January 2 2026
Active Locations (1)
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1
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States, 98108-1532