Status:
UNKNOWN
Endometrial Preparation by Short Course of Letrozole Before Hysteroscopic Removal of Endocavitary Lesions
Lead Sponsor:
Mansoura University
Conditions:
Myoma;Uterus
Eligibility:
FEMALE
18-45 years
Phase:
PHASE4
Brief Summary
The aim of this study is to evaluate the effectiveness of short course of letrozole for endometrial preparation before hysteroscopic surgery for intracavitary lesions.
Detailed Description
In the cycle subsequent to hysteroscopic identification of an endouteine pathology, patients who fitted with the inclusion criteria will be randomly divided into two groups; letrozole group (study gro...
Eligibility Criteria
Inclusion
- Patients with endouterine pathologies, identified by office diagnostic hysteroscopy during the early endometrial proliferative phase (cycle days 7 to 8)
Exclusion
- Presence of large submucous (type I, type II) or endocavitary (type 0) fibroids (according to the European Society of Hysteroscopy Classification of Submucous Fibroids) with a diameter exceeding 4 cm, for which preoperative treatment with GnRH agonists is indicated.
- Hormonal therapies in the previous 8 weeks (including the drug of the study).
- Uterine and/or concomitant adnexal pathologies (including malignancy) for which hysteroscopic surgery was not considered either safe or the method to resolve the problem.
- Cardiovascular, hepatic, or renal impairment.
- Allergy to letrozole.
Key Trial Info
Start Date :
May 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04364581
Start Date
May 1 2020
End Date
May 1 2021
Last Update
April 28 2020
Active Locations (1)
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1
Mansoura University Hospital
Al Mansurah, Dakahlia Governorate, Egypt, 35111