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Status:

COMPLETED

Speech Entrainment for Aphasia Recovery

Lead Sponsor:

Medical University of South Carolina

Collaborating Sponsors:

National Institute on Deafness and Other Communication Disorders (NIDCD)

Conditions:

Aphasia

Aphasia Non Fluent

Eligibility:

All Genders

21-81 years

Phase:

PHASE2

Brief Summary

After a stroke, many people experience a language impairment called aphasia. One of the most debilitating types of aphasia is non-fluent aphasia. Non-fluent aphasia is defined by significantly reduced...

Eligibility Criteria

Inclusion

  • Inclusion Criteria
  • Aphasia as a result of a left hemisphere ischemic or hemorrhagic stroke (WAB-R Aphasia Quotient \<93.8).
  • Presence of left hemisphere stroke in clinical imaging (CT/MRI) and NIHSS
  • Participants must have spoken English as their primary language.
  • 21-81 years old
  • Pre-stroke modified Rankin Scale (mRS)= 2 or less
  • Post-stroke mRS= 4 or less.
  • At least 6 months post-stroke.
  • Non-fluent aphasia (WAB-R Comprehension score \>4 and WAB-R Fluency score \<6).
  • Technological compatibility (to be determined by clinical judgment of SLP)
  • Exclusion Criteria
  • History of chronic neurological or psychiatric diseases (excluding migraines, depression, or post-stroke epilepsy). Self-reported history of learning disability.
  • Severe dysarthria (determined via SLP clinical judgment from spontaneous speech tasks on the ASRS 3.0).
  • Global aphasia.
  • History of right-hemisphere strokes or brain stem/cerebellar strokes with persistent deficits (as evidenced by MRI/CT and NIHSS).
  • Uncorrectable hearing as determined by the SLP's clinical judgment.
  • Uncorrectable vision.
  • Contraindications to MRI or inability to complete the MRI scanning session.
  • Women who are pregnant.

Exclusion

    Key Trial Info

    Start Date :

    August 21 2020

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    August 31 2025

    Estimated Enrollment :

    80 Patients enrolled

    Trial Details

    Trial ID

    NCT04364854

    Start Date

    August 21 2020

    End Date

    August 31 2025

    Last Update

    November 14 2025

    Active Locations (3)

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    Page 1 of 1 (3 locations)

    1

    Medical University of South Carolina

    Charleston, South Carolina, United States, 29401

    2

    University of South Carolina

    Columbia, South Carolina, United States, 29208

    3

    University of Utah

    Salt Lake City, Utah, United States, 84112